The protocol describes a method for generating induced pluripotent stem cells (iPSCs) from human dermal fibroblasts using non-modified RNAs (NM-RNAs) and immune evasion factors, avoiding viral or integrating methods. This approach aims to introduce key genes that regulate and maintain the pluripotent cell state while reducing cellular defense mechanisms.

Europe has around 31 million cryptocurrency users, with Eastern European countries leading in crypto investments according to the 2023 Global Crypto Adoption Index by Chainalysis. Ukraine, Turkey, and Russia top the list in Europe, while the UK and Spain follow. Globally, Asia dominates with India, Nigeria, and Vietnam leading in grassroots crypto adoption. The overall market capitalization of cryptocurrencies has risen to $2.44 trillion, and Europe hosts over 1,100 blockchain-related entities worth $185 billion.

Cryptocurrency adoption varies significantly across Europe, with Eastern European countries like Ukraine, Turkey, and Russia leading in investment. The UK and Spain follow in Western Europe. Globally, Asia, particularly India, dominates cryptocurrency adoption, with significant contributions from Nigeria and Vietnam. The overall market capitalization of cryptocurrencies has surged, reflecting their growing integration into traditional financial systems. Europe hosts over 1,100 blockchain-related entities, primarily in Switzerland, Liechtenstein, and northern Italy, contributing significantly to the sector's value.

European researchers have initiated a clinical trial to explore the efficacy and safety of psilocybin, a compound found in magic mushrooms, in alleviating psychological distress in palliative care patients with advanced illnesses. The EU has allocated over €6.5 million to the project, named PsyPal, which will be conducted across clinics in the Netherlands, Czechia, Denmark, and Portugal. The trial, coordinated by the Dutch University Medical Centre Groningen, will involve over 100 patients and focus on conditions such as COPD, MS, ALS, and atypical Parkinson’s disease. The study aims to start in early 2025, with results expected by 2027.

Daily consumption of meat-based and processed foods is linked to the development of Alzheimer's disease, according to a study by Bond University in Australia. Researchers found a strong association between these foods and the degenerative brain disorder after studying 438 people, with those diagnosed with Alzheimer's regularly consuming processed foods and fewer fruits and vegetables. Lead author Tahera Ahmed, who has a personal connection to the disease, hopes the research will encourage healthier eating habits among young people. Previous studies have also found similar links between meat-heavy diets and Alzheimer's disease.

Scientists have identified a potential reason why women are more prone to autoimmune diseases than men, attributing it to the presence of two X chromosomes in females. A study by Stanford University researchers, published in Cell, found that the molecule Xist, which inactivates one of the X chromosomes to prevent protein overproduction, can also trigger autoimmune responses. Experiments on male lab mice with a modified Xist gene showed similar autoimmune responses to females when exposed to an irritant. This discovery could enhance the detection and treatment of autoimmune conditions.

New guidelines from the Royal College of Obstetricians and Gynaecologists (RCOG) state that healthcare professionals are not legally required to report suspected illegal abortions to the police, emphasizing patient confidentiality and compassionate care. The guidelines come amid rising police investigations into later gestation abortions and pregnancy losses in the UK. The RCOG aims to remove abortion care from criminal law, placing it under medical regulation. Abortion laws vary across the UK and the EU, with most countries allowing abortion on request within specific gestation limits, except for Poland and Malta, which have highly restrictive laws.

The World Health Organization has raised alarms over a significant increase in measles cases in Europe, with a 30-fold rise in 2023 compared to the previous year. Over 30,000 cases were reported in 40 out of 53 European countries, leading to 21,000 hospitalizations and five deaths. The UK and Romania are among the hardest hit, with the UK declaring a 'national incident' and Romania experiencing an epidemic. Austria, France, and Germany have also reported notable outbreaks. The European Centre for Disease Prevention and Control and WHO attribute the resurgence to suboptimal vaccination coverage, which has declined since 2020. Health authorities stress the importance of receiving two doses of the MMR vaccine to prevent the spread of the highly contagious virus.

The eurozone's unemployment rate decreased to 6.4% in November 2023, down from 6.5% in October and 6.7% the previous year, according to Eurostat. The EU's overall unemployment rate also fell to 5.9%. Youth unemployment in both the EU and eurozone was 14.5%. Switzerland's unemployment rate dropped to 2%, its lowest since 2001, while Italy's rate fell to 7.5% with youth unemployment at 21%.

Boeing's shares fell 9% after the FAA grounded 171 of its 737 MAX 9 jets for safety checks following an incident where part of an Alaska Airlines jet's fuselage tore off. Airbus shares rose over 1%, with the company expected to announce record deliveries and orders, maintaining its position as the world's biggest planemaker. Shares of Boeing's suppliers and customers, including Spirit Aero, Alaska Air, and United Airlines, also dropped. The Boeing incident is anticipated to affect the Dow Jones Industrial Average, with Dow Futures already down 188 points. Boeing's CEO Dave Calhoun emphasized the company's focus on responding to the incident, with a safety webcast planned.