The study investigates the potential of circulating cancer-associated macrophage-like cells (CAM-Ls) as predictive biomarkers for immune checkpoint inhibitor (ICI) response in non-small-cell lung cancer (NSCLC) patients. It highlights the inverse relationship between CAM-Ls and circulating tumor cells (CTCs), suggesting that a lower CTC/CAM-L ratio correlates with better progression-free survival (PFS) and overall survival (OS). The research underscores the significance of CAM-Ls in evaluating ICI treatment efficacy, proposing them as a non-invasive biomarker for cancer immunotherapy. The study is based on a retrospective analysis of archived CellSearch® images from NSCLC patients in Italy.

Managing future uncertainty in investment strategies involves a disciplined approach to mitigate panic and irrational behavior. Holding 'income' solutions offers a significant defense in volatile markets. Generating cash flows during volatility reassures investors by providing liquidity for reallocation, especially amid inflation concerns. Diversified portfolios in terms of asset classes and currencies are crucial. Invesco focuses on inflation-indexed bonds and high-yield short-term credit exposure. Millennials and Gen Z share similar financial goals with previous generations but differ in communication methods. Financial advisors can bridge generational gaps in financial education.

Assoreti has appointed Massimo Doris as its new president for the 2023-2026 term. The board of directors includes several confirmed and new members. Massimo Doris, with a background in political science and extensive experience in the financial sector, has held various leadership roles at Banca Mediolanum and other financial institutions. The assembly also confirmed the members of the Giurì d’Onore and the management committee for the current term.

Generali has sold Generali Deutschland Pensionskasse AG (GDPK) to Frankfurter Leben, with the transaction expected to complete by 2023 pending regulatory approvals. The sale aligns with Generali's strategic plan to optimize its life insurance portfolio and improve profitability. Frankfurter Leben will acquire approximately 150,000 pension fund contracts, marking its fifth acquisition in the German life insurance market. The transaction is expected to increase the Solvency Ratio in Germany and globally by about 1%. Generali's de-risking strategy began in 2019 with the sale of a majority stake in Generali Leben.

In the current volatile market context, a sophisticated and new approach is necessary. Giovanni De Mare, head of Italy at AllianceBernstein, emphasizes the importance of sticking to long-term plans and suggests strategies like long-short to manage volatility. Persistent inflation poses significant challenges, and investors should seek companies that can maintain profit margins. Climate change and AI also have profound implications for investors, with AI tools like AllianceBernstein's Abbie enhancing decision-making and efficiency.

Eurostat data from 2022 reveals that 7% of European workers are working more hours than required, with Italy having one of the highest percentages in Europe. Approximately 2.7 million Italian workers work 50 hours a week, surpassing the standard 40 hours. In response to the need for better work-life balance post-COVID-19, Italian unions are pressuring the government to adopt a shorter work week. While Prime Minister Giorgia Meloni has shown openness to the idea, no decision has been made. Some companies, like Tria spa, Toyota Material Handling, and Intesa Sanpaolo, are already experimenting with shorter work weeks or reduced hours.

BKN301, a fintech company specializing in payment services and Banking-as-a-Service, has completed a Series A funding round of 15 million euros, bringing its total valuation to 63 million euros. The round was led by the Swiss fund Abalone Group, with participation from Azimut through its venture capital vehicle Azimut Digitech Fund, and other investors including PayU, Crif, and GNB Swiss Investments AG. The capital will be used to further develop the company's open banking platform and expand in emerging markets such as Africa, the Middle East, and Eastern Europe. The board of BKN301 will see new additions from various financial institutions. Co-founder and CEO Stiven Muccioli emphasized the importance of this funding round in validating the company's growth strategy in fast-growing markets.

The article discusses the challenges and opportunities for asset servicers in adopting new DLT/blockchain technologies, driven by the industry's quest for efficiency. Marco Mosca of Societe Generale Securities Services (SGSS) highlights the importance of tokenized funds and strategic partnerships, such as those with Fundstore.it and MFEX by Euroclear, to offer comprehensive services and maintain cost efficiency. SGSS aims to provide a one-stop-shop solution for institutional investors, leveraging technology to enhance operational, economic, and relational efficiency. SG FORGE, a startup by Société Générale, is noted for its success in utilizing blockchain for capital markets, offering products like bonds and utility tokens.

Wealth managers need to revise their engagement strategies to attract High Net Worth Individuals (HNWIs), as highlighted in the World Wealth Report by Capgemini. The report, covering 71 markets, indicates that the HNWI population is evolving, with increasing numbers of women, LGBTQ+ individuals, millennials, and Gen Z seeking wealth management services. These groups have unique preferences and needs, often unmet by current providers. Wealth managers must offer personalized experiences, digital solutions, and emphasize ESG factors to meet these demands. The role of Chief Customer Officer is becoming crucial in fostering client relationships and leveraging digital benefits.

Schroders has devalued its stake in the British fintech company Revolut by approximately 46%, reducing the valuation from $33 billion to $17.7 billion. This decision follows Revolut's 2022 financial report, which, despite showing the company's first annual profit, raised concerns from auditor BDO about the accuracy of reported revenues. Schroders cited the challenging market environment as the reason for the devaluation. Revolut has addressed the auditor's concerns and continues to perform well across its markets.