Lytic cell death, which results in plasma membrane rupture (PMR), is mediated by the effector membrane protein NINJ1. The study reveals that NINJ1 is autoinhibited in its inactive state by forming a face-to-face homodimer, preventing PMR and ensuring cell survival. Using cryogenic electron microscopy, researchers identified the structure of inactive NINJ1 bound to a nanobody, Nb538. The inactive dimer sequesters the PMR-inducing hydrophilic face and occludes the binding site for activated NINJ1 molecules. Mutagenesis studies indicate that destabilizing these dimers leads to cell death, while stabilizing them inhibits NINJ1 activity. The findings highlight the role of dimeric NINJ1 in preventing unprovoked PMR and cell death.

Harmanpreet Kaur, captain of the Indian Women's Cricket Team, is preparing to lead her team in the T20 World Cup in the UAE. Despite past inconsistencies in her batting, Kaur remains a key player, known for her aggressive style. The team, bolstered by emerging talents like Jemimah Rodrigues and Richa Ghosh, aims to overcome past setbacks and bring glory to India. Kaur's recent performances have been under scrutiny, but she remains optimistic about playing with freedom and confidence. The article highlights the team's preparation and the challenges they face in the upcoming tournament.

Anmoljeet Singh, a 17-year-old off-spinner from Ludhiana, has been selected for the India U19 squad to play against Australia U19 in Chennai. Known for his ability to flight and deceive batters, he has impressed coaches and selectors, including Punjab U19 coach Ravneet Ricky. Anmoljeet, who idolizes Harbhajan Singh, has shown significant progress in his bowling skills and fitness, earning accolades such as the 'Emerging Player' award. His aspirations include playing in the U-19 World Cup in 2026 and making his Ranji Trophy debut for Punjab.

Kerala cricketer Minnu Mani, from the Kurichiya tribe in Wayanad, has made significant strides in her career. She became the only player from the state to join the inaugural Women's Premier League (WPL) after being bought by Delhi Capitals for Rs.30 lakh. Additionally, she made a successful India T20 debut against Bangladesh last month.

The Afghanistan cricket team, accustomed to harsh winter temperatures back home, is preparing for the first T20I against India at the Punjab Cricket Association Stadium in Mohali, despite the severe cold weather conditions.

The Indian cricket board is set to host two women's Tests where India will play against England and Australia this month. However, there is an irony in the fact that the board does not conduct any domestic red-ball tournament.

Minerva Academy Football Club made history by becoming the first Indian team to win the Gothia Cup (U-13), defeating Brazilian team Ordin FC 3-1 in the final of the tournament, which is also known as the 'World Youth Cup'.

The inaugural Sher-e-Punjab T20 Cup concluded with BLV Blasters winning the trophy at the IS Bindra PCA Stadium in Mohali, witnessed by a packed crowd. The tournament, which had a low-key start, ended on a high note with the final match played under floodlights.

India secured a five-wicket win over Australia in a cricket match, with a notable performance from Shami. The victory is seen as a good workout, though concerns were raised about the need for improved fielding and catching ahead of the World Cup.